Hyaluronan oligosaccharides are potential stimulators to angiogenesis via RHAMM mediated signal pathway in wound healing
نویسندگان
چکیده
منابع مشابه
Angiogenesis in Wound Healing
Angiogenesis, the formation of new blood vessels from pre-existing, vessels is a crucial process for tumor growth and metastasis (Folkman 1990; Kaafarani, Fernandez-Sauze et al. 2009). The new vessels supply the tumor cells with nutrients and oxygen and ensure efficient drainage of metabolites. Under normal conditions, a tissue or tumor cannot grow beyond 1 to 2 mm in diameter without neovascul...
متن کاملTortuous Microvessels Contribute to Wound Healing via Sprouting Angiogenesis
OBJECTIVE Wound healing is accompanied by neoangiogenesis, and new vessels are thought to originate primarily from the microcirculation; however, how these vessels form and resolve during wound healing is poorly understood. Here, we investigated properties of the smallest capillaries during wound healing to determine their spatial organization and the kinetics of formation and resolution. APP...
متن کاملThe role of hyaluronan in wound healing.
The polysaccharide hyaluronan (HA) (synonyms - hyaluronic acid, hyaluronate) is a versatile, polymorphic, glycosoaminoglycan with vast biological functions. HA is found throughout the body, primarily residing in skin, thus playing an important role in wound healing. Research regarding HA's function has changed over the years, primarily focussing on a particular aspect or function. The contribut...
متن کاملRhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
Rhamm (receptor for hyaluronan-mediated motility) is an hyaluronan binding protein with limited expression in normal tissues and high expression in advanced cancers. To understand its physiological functions and identify the molecular mechanisms underlying these functions, we created mice with a genetic deletion of Rhamm. We show that Rhamm(-/-) fibroblasts fail to resurface scratch wounds >3 m...
متن کاملLocal injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis
Impaired angiogenesis contributes to delayed wound healing in aging. Hyaluronan (HA) has a close relationship with angiogenesis and wound healing. However, HA content decreases with age. In this study, we used high molecular weight HA (HMW-HA) (1650 kDa), and investigated its effects on wound healing in old rats by local injection. We found that HMW-HA significantly increases proliferation, mig...
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ژورنال
عنوان ژورنال: Clinical & Investigative Medicine
سال: 2008
ISSN: 1488-2353
DOI: 10.25011/cim.v31i3.3467